This workshop will be held in Vienna, following the VIZIER / SPINE2 Workshop on Structural Virology (http://www.vizier-europe.org/article331.html).
It is specifically designed for the crystallographic community in VIZIER and aims to provide training on the different tools developed by Global Phasing Limited (http://www.globalphasing.com/).
Its main products are: (1) SHARP for experimental phasing, using a maximum-likelihood method for refining heavy-atom parameters in the presence of phase uncertainty and its graphical user interface SUSHI which incorporates a powerful script for density modification using SOLOMON; (2) autoSHARP, a system of scripts for automated structure solution from experimental phase information, using RANTAN for heavy-atom detection and scripts for driving ARP/wARP in an optimal fashion; (3) BUSTER for maximum-likelihood structure refinement, using the TNT refinement package of the US developers L. Ten Eyck and D. Tronrud and providing a maximum-entropy completion capability for partial models.
The “production version” of Global Phasing’s software is distributed for free to academic institutions over the entire world. SHARP/autoSHARP is now installed on over 700 machines in over 500 academic laboratories. The recently released SHARP 2.0 is the outcome of 6 man-years of additional work, entirely financed by the pharmaceutical industry, on improving the speed and performance of the previous version. Speedup factors ranging from 15 (for small problems) to 200 (for large ones) have been achieved, as well as marked improvements in the final results.
For more information about this event and registrations, send an email to structural.virology@univie.ac.at
VIZIER internal Training Course on Global Phasing Software
