In recent years it was established that eucaryotic genomes code for a high proportion of intrinsically unstructured proteins (PINS). These proteins are functional despite lack of stable secondary and tertiary structures under physiological conditions. Structural disorder, partial or global, is also found in a number of proteins implicated in severe neurodegenerative diseases (Alzheimer, prion, Parkinson...), and also in some viral pathologies.
The main goal of this workshop is to familiarize participants with structural disorder and induced folding (the disorder to order transition that PINS can undergo upon interaction with their physiological partners). This workshop also aims at providing present knowledge of the role of these proteins, their propensity to fold, the molecular mechanisms that control folding and unfolding, and the impact of these latter phenomena in terms of functional implications and of relationships with various pathologies.
The closing date for applications is 4th May 2007. For further information and to apply for participation see the official website: http://www.inserm.fr
INSERM Workshop on "Intrinsically unstructured proteins and associated pathologies: prediction, characterization and function"
