VIZIER:Publications des partenaires du projet VIZIER, dans le domaine de la virologie et de la génomique structurale

181. Silvia Speroni, Jacques Rohayem, Simone Nenci, Daniele Bonivento, Ivonne Robel, Julia Barthel, Victor B. Luzhkov, Bruno Coutard, Bruno Canard and Andrea Mattevi Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 Å resolution Journal of Molecular Biology
Abstract \| Link \| PDB

180. Graham SC, Assenberg R, Delmas O, Verma A, Gholami A, Talbi C, Owens RJ, Stuart DI, Grimes JM, Bourhy H. Rhabdovirus matrix protein structures reveal a novel mode of self-association. PLoS Pathog. 2008 Dec;4(12):e1000251. Epub 2008 Dec 26.
Abstract \| PubMed \| PDB

179. Lieutaud P, Canard B, Longhi S. MeDor: a metaserver for predicting protein disorder. BMC Genomics. 2008 Sep 16;9 Suppl 2:S25
Abstract \| PubMed

178. De Palma AM, Heggermont W, Lanke K, Coutard B, Bergmann M, Monforte AM, Canard B, De Clercq E, Chimirri A, Pürstinger G, Rohayem J, van Kuppeveld F, Neyts J. The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C. J Virol
Abstract \| PubMed

177. Forrester NL, Moss SR, Turner SL, Schirrmeier H, Gould EA. Recombination in rabbit haemorrhagic disease virus: Possible impact on evolution and epidemiology. Virology. 2008 May 1.
Abstract \| PubMed

176. Decroly E, Imbert I, Coutard B, Bouvet M, Selisko B, Alvarez K, Gorbalenya AE, Snijder EJ, Canard B. Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity. J. Virol
Abstract \| PubMed

175. elmas O, Holmes EC, Talbi C, Larrous F, Dacheux L, Bouchier C, Bourhy H. Genomic diversity and evolution of the Lyssaviruses. PLoS ONE. 2008 Apr 30;3(4):e2057.
Abstract \| PubMed

174. Assenberg R, Delmas O, Graham SC, Verma A, Berrow N, Stuart DI, Owens RJ, Bourhy H, Grimes JM. Expression, purification and crystallization of a lyssavirus matrix (M) protein. Acta F
Abstract \| PubMed

173. de Lamballerie X, Leroy E, Charrel RN, Ttsetsarkin K, Higgs S, Gould EA. Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come? Virol J. 2008 Feb 27;5:33.
Abstract \| PubMed

172. Speroni S, De Colibus L, Mastrangelo E, Gould E, Coutard B, Forrester NL, Blanc S, Canard B, Mattevi A. Structure and biochemical analysis of Kokobera virus helicase. Proteins. 2008 Feb 15;70(3):1120-3.
Abstract \| PubMed \| PDB

171. Leontovich AM, Tokmachev KY, van Houwelingen HC. The comparative analysis of statistics, based on the likelihood ratio criterion, in the automated annotation problem. BMC Bioinformatics. 2008 Jan 22;9:31.
Abstract \| PubMed

170. Mumtsidu E, Makhov AM, Roessle M, Bathke A, Tucker PA. Structural features of the Bluetongue virus NS2 protein. J Struct Biol. 2007 Nov;160(2):157-67.
Abstract \| PubMed

169. Mancini EJ, Assenberg R, Verma A, Walter TS, Tuma R, Grimes JM, Owens RJ, Stuart DI. Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution. Protein Sci. 2007 Oct;16(10):2294-300.
Abstract \| PubMed

168. Jiang P, Faase JA, Toyoda H, Paul A, Wimmer E, Gorbalenya AE. Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication. PNAS U S A. 2007 May 29;104(22):9457-62.
Abstract \| PubMed

167. Assenberg R, Ren J, Verma A, Walter TS, Alderton D, Hurrelbrink RJ, Fuller SD, Bressanelli S, Owens RJ, Stuart DI, Grimes JM. Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. J Gen Virol. 2007 Aug;88(Pt 8):2228-36.
Abstract \| PubMed

166. Grard G, Moureau G, Charrel RN, Lemasson JJ, Gonzalez JP, Gallian P, Gritsun TS, Holmes EC, Gould EA, de Lamballerie X. Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy. Virology. 2007 Apr 25;361(1):80-92.
Abstract \| PubMed

165. Fullerton SW, Blaschke M, Coutard B, Gebhardt J, Gorbalenya A, Canard B, Tucker PA, Rohayem J. Structural and functional characterization of sapovirus RNA-dependent RNA polymerase. J Virol. 2007 Feb;81(4):1858-71.
Abstract \| PubMed

164.

Coutard B, Gorbalenya AE, Snijder EJ, Leontovich AM, Poupon A, De Lamballerie X, Charrel R, Gould EA, Gunther S, Norder H, Klempa B, Bourhy H, Rohayem J, L'hermite E, Nordlund P, Stuart DI, Owens RJ, Grimes JM, Tucker PA, Bolognesi M, Mattevi A, Coll M, Jones TA, Aqvist J, Unge T, Hilgenfeld R, Bricogne G, Neyts J, La Colla P, Puerstinger G, Gonzalez JP, Leroy E, Cambillau C, Romette JL, Canard B.

The VIZIER project: Preparedness against pathogenic RNA viruses.

Antiviral Res.

Abstract | PubMed

163. Care S, Bignon C, Pelissier MC, Blanc E, Canard B, Coutard B. The translation of recombinant proteins in E. coli can be improved by in silico generating and screening random libraries of a 70/+96 mRNA region with respect to the translation initiation codon. Nucleic Acids Res.
Abstract \| PubMed

162.

Paeshuyse J, Chezal JM, Froeyen M, Leyssen P, Dutartre H, Vrancken R, Canard B, Letellier C, Li T, Mittendorfer H, Koenen F, Kerkhofs P, De Clercq E, Herdewijn P, Puerstinger G, Gueiffier A, Chavignon O, Teulade JC, Neyts J.

The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.

Journal of Virology, Oct. 2007, p. 11046-11053

Abstract | PubMed

161. Egloff MP, Decroly E, Malet H, Selisko B, Benarroch D, Ferron F, Canard B. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. J Mol Biol. 2007 Sep 21;372(3):723-36. Epub 2007 Jul 12.
Abstract \| PubMed \| PDB

160. Mastrangelo E, Milani M, Bollati M, Selisko B, Peyrane F, Pandini V, Sorrentino G, Canard B, Konarev PV, Svergun DI, de Lamballerie X, Coutard B, Khromykh AA, Bolognesi M. Crystal structure and activity of kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein. J Mol Biol. 2007 Sep 14;372(2):444-55. Epub 2007 Jun 27.
Abstract \| PubMed \| PDB

159. Beerens N, Selisko B, Ricagno S, Imbert I, van der Zanden L, Snijder EJ, Canard B. De novo initiation of RNA synthesis by the arterivirus RNA-dependent RNA polymerase J Virol. 2007 Aug;81(16):8384-95. Epub 2007 May 30.
Abstract \| PubMed

158. Assenberg R, Ren J, Verma A, Walter TS, Alderton D, Hurrelbrink RJ, Fuller SD, Bressanelli S, Owens RJ, Stuart DI, Grimes JM. Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase J Gen Virol. 2007 Aug;88(Pt 8):2228-36.
Abstract \| PubMed \| PDB

157. Mastrangelo E, Bollati M, Milani M, Selisko B, Peyrane F, Canard B, Grard G, de Lamballerie X, Bolognesi M. Structural bases for substrate recognition and activity in Meaban virus nucleoside-2'-O-methyltransferase. Protein Sci. 2007 Jun;16(6):1133-45. Epub 2007 May 1.Click here to read
Abstract \| PubMed

156. Malet H, Egloff MP, Selisko B, Butcher RE, Wright PJ, Roberts M, Gruez A, Sulzenbacher G, Vonrhein C, Bricogne G, Mackenzie JM, Khromykh AA, Davidson AD, Canard B. Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5. J Biol Chem. 2007 Apr;282(14):10678-89. Epub 2007 Feb 7.
Abstract \| PubMed \| PDB

155. De Colibus L, Speroni S, Coutard B, Forrester NL, Gould E, Canard B, Mattevi A Purification and crystallization of Kokobera virus helicase Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):193-5.
Abstract \| PubMed

154. Sutton G, Grimes JM, Stuart DI, Roy P. Bluetongue virus VP4 is an RNA-capping assembly line. Nat Struct Mol Biol. 2007 May;14(5):449-51.
Abstract \| PubMed \| PDB

153. Nick S. Berrow, David Alderton, Sarah Sainsbury, Joanne Nettleship, Rene Assenberg, Nahid Rahman, David I. Stuart, and Raymond J. Owens A versatile ligation-independent cloning method suitable for high-throughput expression screening applications Nucleic Acids Res. 2007 Mar 12; [Epub ahead of print]
Abstract \| PubMed

152. Yap TL, Xu T, Chen YL, Malet H, Egloff MP, Canard B, Vasudevan SG, Lescar J. Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. J Virol. 2007 May;81(9):4753-65. Epub 2007 Feb 14.
Abstract \| PubMed \| PDB

151. Peyrane F, Selisko B, Decroly E, Vasseur JJ, Benarroch D, Canard B, Alvarez K High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions Nucleic Acids Res. 2007 Jan 26; [Epub ahead of print]
Abstract \| PubMed

150. Biagini P, de Lamballerie X, de Micco P. Effective detection of highly divergent viral genomes in infected cell lines using a new subtraction strategy (primer extension enrichment reaction-PEER). J Virol Methods. 2007 Jan;139(1):106-10. Epub 2006 Oct 25
Abstract \| PubMed

149. Barral K, Priet S, Sire J, Neyts J, Balzarini J, Canard B, Alvarez K. Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine. J Med Chem. 2006 Dec 28;49(26):7799-7806.
Abstract \| PubMed

148. Palma AM, Heggermont W, Leyssen P, Purstinger G, Wimmer E, Clercq ED, Rao A, Monforte AM, Chimirri A, Neyts J. Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles. Biochem Biophys Res Commun. 2006 Dec 19
Abstract \| PubMed

147. Dutartre H, Bussetta C, Boretto J, Canard B. General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2'-modified nucleotide analogues. Antimicrob Agents Chemother. 2006 Dec;50(12):4161-9.
Abstract \| PubMed

146. Emmerich P, Thome-Bolduan C, Drosten C, Gunther S, Ban E, Sawinsky I, Schmitz H. Reverse ELISA for IgG and IgM antibodies to detect Lassa virus infections in Africa. J Clin Virol. 2006 Dec;37(4):277-81.
Abstract \| PubMed

145. Hass M, Westerkofsky M, Muller S, Becker-Ziaja B, Busch C, Gunther S. Mutational analysis of the lassa virus promoter. J Virol. 2006 Dec;80(24):12414-9.
Abstract \| PubMed

144. Mesters JR, Tan J, Hilgenfeld R. Viral enzymes. Curr Opin Struct Biol. 2006 Dec;16(6):776-86.
Abstract \| PubMed

143. Stikleryte A, Griskeviciene J, Magnius LO, Zagminas K, Norder H, Ambrozaitis A. Characterization of HCV strains in an oncohematological pediatric department reveals little horizontal transmission but multiple introductions by un-screened blood products in the past. J Med Virol. 2006 Nov;78(11):1411-22.
Abstract \| PubMed

142. Sassenscheidt J, Rohayem J, Illmer T, Bandt D. Detection of beta-herpesviruses in allogenic stem cell recipients by quantitative real-time PCR. J Virol Methods. 2006 Dec;138(1-2):40-8.
Abstract \| PubMed

141. van Aken D, Zevenhoven-Dobbe J, Gorbalenya AE, Snijder EJ. Proteolytic maturation of replicase polyprotein pp1a by the nsp4 main proteinase is essential for equine arteritis virus replication and includes internal cleavage of nsp7. J Gen Virol. 2006 Dec;87(Pt 12):3473-82.
Abstract \| PubMed

140. Mesters JR, Tan J, Hilgenfeld R. Viral enzymes. Curr Opin Struct Biol. 2006 Dec;16(6):776-86. Epub 2006 Nov 7
Abstract \| PubMed

139. Fullerton SW, Blaschke M, Coutard B, Gebhardt J, Gorbalenya A, Canard B, Tucker PA, Rohayem J. STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF SAPOVIRUS RNA-DEPENDENT RNA POLYMERASE. J Virol. 2006 Nov 22
Abstract \| PubMed

138. Grard G, Lemasson JJ, Sylla M, Dubot A, Cook S, Molez JF, Pourrut X, Charrel R, Gonzalez JP, Munderloh U, Holmes EC, de Lamballerie X. Ngoye virus: a novel evolutionary lineage within the genus Flavivirus. J Gen Virol. 2006 Nov;87(Pt 11):3273-7.
Abstract \| PubMed

137. Gritsun TS, Gould EA. Direct repeats in the 3' untranslated regions of mosquito-borne flaviviruses: possible implications for virus transmission. J Gen Virol. 2006 Nov;87(Pt 11):3297-305.
Abstract \| PubMed

136. Pattamadilok S, Lee BH, Kumperasart S, Yoshimatsu K, Okumura M, Nakamura I, Araki K, Khoprasert Y, Dangsupa P, Panlar P, Jandrig B, Kruger DH, Klempa B, Jakel T, Schmidt J, Ulrich R, Kariwa H, Arikawa J. Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus. Am J Trop Med Hyg. 2006 Nov;75(5):994-1002.
Abstract \| PubMed

135. Tataridis D, Fytas G, Kolocouris A, Fytas C, Kolocouris N, Foscolos GB, Padalko E, Neyts J, De Clercq E. Influence of an additional 2-amino substituent of the 1-aminoethyl pharmacophore group on the potency of rimantadine against influenza virus A. Bioorg Med Chem Lett. 2006 Nov 2
Abstract \| PubMed

134. Ying C, Colonno R, De Clercq E, Neyts J. Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir. Antiviral Res. 2006 Oct 30
Abstract \| PubMed

133. Puerstinger G, Paeshuyse J, De Clercq E, Neyts J. Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: From anti-pestivirus to anti-hepatitis C virus activity. Bioorg Med Chem Lett. 2006 Oct 19
Abstract \| PubMed

132. Puerstinger G, Paeshuyse J, Herdewijn P, Rozenski J, De Clercq E, Neyts J. Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5345-9
Abstract \| PubMed

131. Geerlof A, Brown J, Coutard B, Egloff MP, Enguita FJ, Fogg MJ, Gilbert RJ, Groves MR, Haouz A, Nettleship JE, Nordlund P, Owens RJ, Ruff M, Sainsbury S, Svergun DI, Wilmanns M. The impact of protein characterization in structural proteomics. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1125-36
Abstract \| PubMed

130. Berrow NS, Bussow K, Coutard B, Diprose J, Ekberg M, Folkers GE, Levy N, Lieu V, Owens RJ, Peleg Y, Pinaglia C, Quevillon-Cheruel S, Salim L, Scheich C, Vincentelli R, Busso D. Recombinant protein expression and solubility screening in Escherichia coli: a comparative study. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1218-26
Abstract \| PubMed

129. Ferron F, Longhi S, Canard B, Karlin D. A practical overview of protein disorder prediction methods. Proteins. 2006 Oct 1;65(1):1-14.
Abstract \| PubMed

128.

Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B, Carrondo M, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider G, Schnell R, Stuart DI, Tarbouriech N, Unge T, Wilkinson AJ, Wilmanns M, Wilson KS, Zimhony O, Grimes JM.

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1196-207

Abstract | PubMed

127. Imbert I, Guillemot JC, Bourhis JM, Bussetta C, Coutard B, Egloff MP, Ferron F, Gorbalenya AE, Canard B. A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus. EMBO J. 2006 Oct 18;25(20):4933-42
Abstract \| PubMed

126. Scandella E, Eriksson KK, Hertzig T, Drosten C, Chen L, Gui C, Luo X, Shen J, Shen X, Siddell SG, Ludewig B, Jiang H, Gunther S, Thiel V. Identification and evaluation of coronavirus replicase inhibitors using a replicon cell line. Adv Exp Med Biol. 2006;581:609-13.
Abstract \| PubMed

125. Ponnusamy R, Mesters JR, Ziebuhr J, Moll R, Hilgenfeld R. Non structural proteins 8 and 9 of human coronavirus 229E. Adv Exp Med Biol. 2006;581:49-54.
Abstract \| PubMed

124. Piotrowski Y, van der Hoek L, Pyrc K, Berkhout B, Moll R, Hilgenfeld R. Nonstructural proteins of human coronavirus NL63. Adv Exp Med Biol. 2006;581:97-100.
Abstract \| PubMed

123. Hilgenfeld R, Anand K, Mesters JR, Rao Z, Shen X, Jiang H, Tan J, Verschueren KH. Structure and dynamics of SARS coronavirus main proteinase (Mpro). Adv Exp Med Biol. 2006;581:585-91
Abstract \| PubMed

122. Morice Y, Cantaloube JF, Beaucourt S, Barbotte L, De Gendt S, Goncales FL, Butterworth L, Cooksley G, Gish RG, Beaugrand M, Fay F, Fay O, Gonzalez JE, Martins RM, Dhumeaux D, Vanderborght B, Stuyver L, Sablon E, de Lamballerie X, Pawlotsky JM. Molecular epidemiology of hepatitis C virus subtype 3a in injecting drug users. J Med Virol. 2006 Oct;78(10):1296-303.
Abstract \| PubMed

121. Marriott L, Willoughby K, Chianini F, Dagleish MP, Scholes S, Robinson AC, Gould EA, Nettleton PF. Detection of Louping ill virus in clinical specimens from mammals and birds using TaqMan RT-PCR. J Virol Methods. 2006 Oct;137(1):21-8.
Abstract \| PubMed

120. Forrester NL, Trout RC, Gould EA. Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire. Virology. 2006 Oct 12
Abstract \| PubMed

119. Gritsun TS, Gould EA. The 3' untranslated region of tick-borne flaviviruses originated by the duplication of long repeat sequences within the open reading frame. Virology. 2006 Oct 10;354(1):217-23.
Abstract \| PubMed

118. Goris N, De Palma A, Toussaint JF, Musch I, Neyts J, De Clercq K. 2'-C-Methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus. Antiviral Res. 2006 Oct 10
Abstract \| PubMed

117. Charrel RN, Retornaz K, Emonet S, Noel G, Chaumoitre K, Minodier P, Girard N, Garnier JM, de Lamballerie X. Acquired hydrocephalus caused by a variant lymphocytic choriomeningitis virus. Arch Intern Med. 2006 Oct 9;166(18):2044-6.
Abstract \| PubMed

116. Setaki D, Tataridis D, Stamatiou G, Kolocouris A, Foscolos GB, Fytas G, Kolocouris N, Padalko E, Neyts J, De Clercq E. Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles. Bioorg Chem. 2006 Oct;34(5):248-73
Abstract \| PubMed

115. Coelmont L, Paeshuyse J, Windisch MP, De Clercq E, Bartenschlager R, Neyts J. Ribavirin antagonizes the in vitro anti-hepatitis C virus activity of 2'-C-methylcytidine, the active component of valopicitabine. Antimicrob Agents Chemother. 2006 Oct;50(10):3444-6
Abstract \| PubMed

114. Paeshuyse J, Coelmont L, Vliegen I, Van hemel J, Vandenkerckhove J, Peys E, Sas B, De Clercq E, Neyts J. Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin. Biochem Biophys Res Commun. 2006 Sep 15;348(1):139-44
Abstract \| PubMed

113. Egloff MP, Malet H, Putics A, Heinonen M, Dutartre H, Frangeul A, Gruez A, Campanacci V, Cambillau C, Ziebuhr J, Ahola T, Canard B. Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains. J Virol. 2006 Sep;80(17):8493-502.
Abstract \| PubMed

112. Marschenz S, Endres AS, Brinckmann A, Heise T, Kristiansen G, Nurnberg P, Kruger DH, Gunther S, Meisel H. Functional analysis of complex hepatitis B virus variants associated with development of liver cirrhosis. Gastroenterology. 2006 Sep;131(3):765-80.
Abstract \| PubMed

111. Gritsun TS, Gould EA. The 3' untranslated regions of Kamiti River virus and Cell fusing agent virus originated by self-duplication. J Gen Virol. 2006 Sep;87(Pt 9):2615-9.
Abstract \| PubMed

110. Buckley A, Dawson A, Gould EA. Detection of seroconversion to West Nile virus, Usutu virus and Sindbis virus in UK sentinel chickens. Virol J. 2006 Sep 4;3:71.
Abstract \| PubMed

109. Rohayem J, Jager K, Robel I, Scheffler U, Temme A, Rudolph W. Characterization of norovirus 3Dpol RNA-dependent RNA polymerase activity and initiation of RNA synthesis. J Gen Virol. 2006 Sep;87(Pt 9):2621-30.
Abstract \| PubMed

108. van Aken D, Benckhuijsen WE, Drijfhout JW, Wassenaar AL, Gorbalenya AE, Snijder EJ. Expression, purification, and in vitro activity of an arterivirus main proteinase. Virus Res. 2006 Sep;120(1-2):97-106. Epub 2006 Mar 9.
Abstract \| PubMed

107. Neyts J. Selective inhibitors of hepatitis C virus replication. Antiviral Res. 2006 Sep;71(2-3):363-71
Abstract \| PubMed

106. Mastrangelo E, Bollati M, Milani M, Brisbarre N, de Lamballerie X, Coutard B, Canard B, Khromykh A, Bolognesi M. Preliminary crystallographic characterization of an RNA helicase from Kunjin virus. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):876-9.
Abstract \| PubMed

105. Ricagno S, Egloff MP, Ulferts R, Coutard B, Nurizzo D, Campanacci V, Cambillau C, Ziebuhr J, Canard B. Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11892-7
Abstract \| PubMed

104. Charrel RN, Izri A, Temmam S, de Lamballerie X, Parola P. Toscana virus RNA in Sergentomyia minuta files. Emerg Infect Dis. 2006 Aug;12(8):1299-300.
Abstract \| PubMed

103. Ottoson J, Hansen A, Westrell T, Johansen K, Norder H, Stenstrom TA. Removal of noro- and enteroviruses, Giardia cysts, Cryptosporidium oocysts, and fecal indicators at four secondary wastewater treatment plants in Sweden. Water Environ Res. 2006 Aug;78(8):828-34.
Abstract \| PubMed

102. Rohayem J, Dumke R, Jaeger K, Schroter-Bobsin U, Mogel M, Kruse A, Jacobs E, Rethwilm A. Assessing the risk of transmission of viral diseases in flooded areas: viral load of the River Elbe in Dresden during the flood of August 2002. Intervirology. 2006;49(6):370-6.
Abstract \| PubMed

101. Mastrangelo E, Bollati M, Milani M, de Lamballeire X, Brisbare N, Dalle K, Lantez V, Egloff MP, Coutard B, Canard B, Gould E, Forrester N, Bolognesi M. Preliminary characterization of (nucleoside-2-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):768-70
Abstract \| PubMed

100. Selisko B, Dutartre H, Guillemot JC, Debarnot C, Benarroch D, Khromykh A, Despres P, Egloff MP, Canard B. Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases. Virology. 2006 Jul 20;351(1):145-58
Abstract \| PubMed

99. Meier C, Aricescu AR, Assenberg R, Aplin RT, Gilbert RJ, Grimes JM, Stuart DI The Crystal Structure of ORF-9b, a Lipid Binding Protein from the SARS Coronavirus. Structure. 2006 Jul;14(7):1157-1165.
Abstract \| PubMed \| PDB

98. Al-Gharabli SI, Shah ST, Weik S, Schmidt MF, Mesters JR, Kuhn D, Klebe G, Hilgenfeld R, Rademann J. An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors. Chembiochem. 2006 Jul;7(7):1048-55.
Abstract \| PubMed

97. de Lamballerie X, Colson P. The battle against infectious diseases in developing countries: the inseparable twins of diagnosis and therapy.de Lamballerie X, Colson P. Clin Chem. 2006 Jul;52(7):1217.
Abstract \| PubMed

96. Beerens N, Snijder EJ. RNA signals in the 3' terminus of the genome of Equine arteritis virus are required for viral RNA synthesis. J Gen Virol. 2006 Jul;87(Pt 7):1977-83.
Abstract \| PubMed

95. Rohayem J, Robel I, Jager K, Scheffler U, Rudolph W. Protein-primed and de novo initiation of RNA synthesis by norovirus 3Dpol. J Virol. 2006 Jul;80(14):7060-9.
Abstract \| PubMed

94. Matthes N, Mesters JR, Coutard B, Canard B, Snijder EJ, Moll R, Hilgenfeld R. The non-structural protein Nsp10 of mouse hepatitis virus binds zinc ions and nucleic acids. FEBS Lett. 2006 Jul 24;580(17):4143-9. Epub 2006 Jun 30.
Abstract \| PubMed

93. Charrel RN, Zaki AM, Fagbo S, de Lamballerie X. Alkhurma hemorrhagic fever virus is an emerging tick-borne flavivirus. J Infect. 2006 Jun;52(6):463-4.
Abstract \| PubMed

92. Cantaloube JF, Laperche S, Gallian P, Bouchardeau F, de Lamballerie X, de Micco P. Analysis of the 5' noncoding region versus the NS5b region in genotyping hepatitis C virus isolates from blood donors in France. J Clin Microbiol. 2006 Jun;44(6):2051-6.
Abstract \| PubMed

91. Snijder EJ, van der Meer Y, Zevenhoven-Dobbe J, Onderwater JJ, van der Meulen J, Koerten HK, Mommaas AM. Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. J Virol. 2006 Jun;80(12):5927-40.
Abstract \| PubMed

90. Pasternak AO, Spaan WJ, Snijder EJ. Nidovirus transcription: how to make sense...? J Gen Virol. 2006 Jun;87(Pt 6):1403-21.
Abstract \| PubMed

89. Zoidis G, Fytas C, Papanastasiou I, Foscolos GB, Fytas G, Padalko E, De Clercq E, Naesens L, Neyts J, Kolocouris N. Heterocyclic rimantadine analogues with antiviral activity. Bioorg Med Chem. 2006 May 15;14(10):3341-8
Abstract \| PubMed

88. Attoui H, Jaafar FM, Belhouchet M, de Micco P, de Lamballerie X, Brussaard CP. Micromonas pusilla reovirus: a new member of the family Reoviridae assigned to a novel proposed genus (Mimoreovirus). J Gen Virol. 2006 May;87(Pt 5):1375-83.
Abstract \| PubMed

87. Klempa B, Fichet-Calvet E, Lecompte E, Auste B, Aniskin V, Meisel H, Denys C, Koivogui L, ter Meulen J, Kruger DH. Hantavirus in African wood mouse, Guinea. Emerg Infect Dis. 2006 May;12(5):838-40.
Abstract \| PubMed

86. Tabarrini O, Manfroni G, Fravolini A, Cecchetti V, Sabatini S, De Clercq E, Rozenski J, Canard B, Dutartre H, Paeshuyse J, Neyts J. Synthesis and anti-BVDV activity of acridones as new potential antiviral agents. J Med Chem. 2006 Apr 20;49(8):2621-7.
Abstract \| PubMed

85. Emonet S, Grard G, Brisbarre N, Moureau G, Temmam S, Charrel R, de Lamballerie X. LoPPS: a long PCR product sequencing method for rapid characterisation of long amplicons. Biochem Biophys Res Commun. 2006 Jun 16;344(4):1080-5. Epub 2006 Apr 19.
Abstract \| PubMed

84. Cook S, Bennett SN, Holmes EC, De Chesse R, Moureau G, de Lamballerie X. Isolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto Rico. J Gen Virol. 2006 Apr;87(Pt 4):735-48.
Abstract \| PubMed

83. Gould EA, Higgs S, Buckley A, Gritsun TS. Potential arbovirus emergence and implications for the United Kingdom. Emerg Infect Dis. 2006 Apr;12(4):549-55.
Abstract \| PubMed

82. Ottoson J, Hansen A, Bjorlenius B, Norder H, Stenstrom TA. Removal of viruses, parasitic protozoa and microbial indicators in conventional and membrane processes in a wastewater pilot plant. Water Res. 2006 Apr;40(7):1449-57.
Abstract \| PubMed

81. Smits SL, Snijder EJ, de Groot RJ. Characterization of a torovirus main proteinase. J Virol. 2006 Apr;80(8):4157-67.
Abstract \| PubMed

80. Leyssen P, De Clercq E, Neyts J. The anti-yellow fever virus activity of ribavirin is independent of error-prone replication. Mol Pharmacol. 2006 Apr;69(4):1461-7
Abstract \| PubMed

79. Paeshuyse J, Kaul A, De Clercq E, Rosenwirth B, Dumont JM, Scalfaro P, Bartenschlager R, Neyts J. The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology. 2006 Apr;43(4):761-70
Abstract \| PubMed

78. Ricagno S, Coutard B, Grisel S, Bremond N, Dalle K, Tocque F, Campanacci V, Lichiere J, Lantez V, Debarnot C, Cambillau C, Canard B, Egloff MP. Crystallization and preliminary X-ray diffraction analysis of Nsp15 from SARS coronavirus. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt 4):409-11
Abstract \| PubMed

77. Malet H, Dalle K, Bremond N, Tocque F, Blangy S, Campanacci V, Coutard B, Grisel S, Lichiere J, Lantez V, Cambillau C, Canard B, Egloff MP. Expression, purification and crystallization of the SARS-CoV macro domain. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt 4):405-8
Abstract \| PubMed

76. Minskaia E, Hertzig T, Gorbalenya AE, Campanacci V, Cambillau C, Canard B, Ziebuhr J. Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5108-13
Abstract \| PubMed

75. Carta A, Loriga M, Piras S, Paglietti G, La Colla P, Busonera B, Collu G, Loddo R. Synthesis of variously substituted 3-phenoxymethyl quinoxalin-2-ones and quinoxalines capable to potentiate in vitro the antiproliferative activity of anticancer drugs in multi-drug resistant cell lines. Med Chem. 2006 Mar;2(2):113-22.
Abstract \| PubMed

74. Schmitz T, Kleinkauf N, Klempa B, Ringe H, Varnholt V, Grosch-Worner I. Transmission of human immunodeficiency virus type 1 nevirapine resistance mutation K103N from a treatment-naive mother to her child. Pediatr Infect Dis J. 2006 Mar;25(3):275-6.
Abstract \| PubMed

73. Gorbalenya AE, Enjuanes L, Ziebuhr J, Snijder EJ. Nidovirales: evolving the largest RNA virus genome. Virus Res. 2006 Apr;117(1):17-37. Epub 2006 Feb 28.
Abstract \| PubMed

72. Emonet S, Lemasson JJ, Gonzalez JP, de Lamballerie X, Charrel RN. Phylogeny and evolution of old world arenaviruses. Virology. 2006 Jul 5;350(2):251-7. Epub 2006 Feb 21.
Abstract \| PubMed

71. Feng JY, Myrick FT, Margot NA, Mulamba GB, Rimsky L, Borroto-Esoda K, Selmi B, Canard B. Virologic and enzymatic studies revealing the mechanism of K65R- and Q151M-associated HIV-1 drug resistance towards emtricitabine and lamivudine. Nucleosides Nucleotides Nucleic Acids. 2006;25(1):89-107.
Abstract \| PubMed

70. Biagini P, de Micco P, de Lamballerie X. Identification of a third member of the Anellovirus genus ("small anellovirus") in French blood donors. Arch Virol. 2006 Feb;151(2):405-8.
Abstract \| PubMed

69. Biagini P, Gallian P, Cantaloube JF, Attoui H, de Micco P, de Lamballerie X. Distribution and genetic analysis of TTV and TTMV major phylogenetic groups in French blood donors. J Med Virol. 2006 Feb;78(2):298-304.
Abstract \| PubMed

68. Posthuma CC, Nedialkova DD, Zevenhoven-Dobbe JC, Blokhuis JH, Gorbalenya AE, Snijder EJ. Site-directed mutagenesis of the Nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle. J Virol. 2006 Feb;80(4):1653-61.
Abstract \| PubMed

67. Paeshuyse J, Leyssen P, Mabery E, Boddeker N, Vrancken R, Froeyen M, Ansari IH, Dutartre H, Rozenski J, Gil LH, Letellier C, Lanford R, Canard B, Koenen F, Kerkhofs P, Donis RO, Herdewijn P, Watson J, De Clercq E, Puerstinger G, Neyts J. A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase. J Virol. 2006 Jan;80(1):149-60.
Abstract \| PubMed

66. Attoui H, Mohd Jaafar F, Belhouchet M, Tao S, Chen B, Liang G, Tesh RB, de Micco P, de Lamballerie X. Liao ning virus, a new Chinese seadornavirus that replicates in transformed and embryonic mammalian cells. J Gen Virol. 2006 Jan;87(Pt 1):199-208.
Abstract \| PubMed

65. Keyaerts E, Vijgen L, Maes P, Duson G, Neyts J, Van Ranst M. Viral load quantitation of SARS-coronavirus RNA using a one-step real-time RT-PCR. Int J Infect Dis. 2006 Jan;10(1):32-7
Abstract \| PubMed

64. Barral K, Balzarini J, Neyts J, De Clercq E, Hider RC, Camplo M. Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives. J Med Chem. 2006 Jan 12;49(1):43-50.
Abstract \| PubMed

63. Bourhis JM, Canard B, Longhi S. Structural disorder within the replicative complex of measles virus: functional implications. Virology. 2006 Jan 5;344(1):94-110.
Abstract \| PubMed

62. Attoui H, Jaafar FM, Belhouchet M, Aldrovandi N, Tao S, Chen B, Liang G, Tesh RB, de Micco P, de Lamballerie X. Yunnan orbivirus, a new orbivirus species isolated from Culex tritaeniorhynchus mosquitoes in China. J Gen Virol. 2005 Dec;86(Pt 12):3409-17.
Abstract \| PubMed

61. Attoui H, Mohd Jaafar F, Belhouchet M, Biagini P, Cantaloube JF, de Micco P, de Lamballerie X. Expansion of family Reoviridae to include nine-segmented dsRNA viruses: Isolation and characterization of a new virus designated aedes pseudoscutellaris reovirus assigned to a proposed genus (Dinovernavirus). Virology. 2005 Dec 20;343(2):212-23. Epub 2005 Sep 19.
Abstract \| PubMed

60. Alvarez K, Deval J, Selmi B, Barral K, Boretto J, Guerreiro C, Mulard L, Sarfati R, Canard B. Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):419-21.
Abstract \| PubMed

59. Tan J, Verschueren KH, Anand K, Shen J, Yang M, Xu Y, Rao Z, Bigalke J, Heisen B, Mesters JR, Chen K, Shen X, Jiang H, Hilgenfeld R. pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses. J Mol Biol. 2005 Nov 18;354(1):25-40.
Abstract \| PubMed

58. Charrel RN, Gallian P, Navarro-Mari JM, Nicoletti L, Papa A, Sanchez-Seco MP, Tenorio A, de Lamballerie X. Emergence of Toscana virus in Europe. Emerg Infect Dis. 2005 Nov;11(11):1657-63.
Abstract \| PubMed

57. Attoui H, Mohd Jaafar F, de Micco P, de Lamballerie X. Coltiviruses and seadornaviruses in North America, Europe, and Asia. Emerg Infect Dis. 2005 Nov;11(11):1673-9
Abstract \| PubMed

56. van den Born E, Stein DA, Iversen PL, Snijder EJ. Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture. J Gen Virol. 2005 Nov;86(Pt 11):3081-90.
Abstract \| PubMed

55. Forrester NL, Abubakr MI, Abu Elzein EM, Al-Afaleq AI, Housawi FM, Moss SR, Turner SL, Gould EA. Phylogenetic analysis of rabbit haemorrhagic disease virus strains from the Arabian Peninsula: did RHDV emerge simultaneously in Europe and Asia? Virology. 2006 Jan 20;344(2):277-82. Epub 2005 Nov 9.
Abstract \| PubMed

54. Ferron F, Bussetta C, Dutartre H, Canard B. The modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases. BMC Bioinformatics. 2005 Oct 14;6:255.
Abstract \| PubMed

53. Omilabu SA, Badaru SO, Okokhere P, Asogun D, Drosten C, Emmerich P, Becker-Ziaja B, Schmitz H, Gunther S. Lassa fever, Nigeria, 2003 and 2004. Emerg Infect Dis. 2005 Oct;11(10):1642-4.
Abstract \| PubMed

52. Yang H, Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, Hilgenfeld R, Yuen KY, Wong L, Gao G, Chen S, Chen Z, Ma D, Bartlam M, Rao Z. Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol. 2005 Oct;3(10):e324.
Abstract \| PubMed

51. Gallian P, De Micco P, de Lamballerie X, Levayer T, Levacon F, Guntz P, Mercier B, Dupond I, Cornillot C, Andreu G. Prevention of West Nile virus transmission by blood transfusion: a comparison of nucleic acid test screening assays. Transfusion. 2005 Sep;45(9):1540-1.
Abstract \| PubMed

50. Gaunt MW, Gould EA. Rapid subgroup identification of the flaviviruses using degenerate primer E-gene RT-PCR and site specific restriction enzyme analysis. J Virol Methods. 2005 Sep;128(1-2):113-27.
Abstract \| PubMed

49. Kramvis A, Restorp K, Norder H, Botha JF, Magnius LO, Kew MC. Full genome analysis of hepatitis B virus genotype E strains from South-Western Africa and Madagascar reveals low genetic variability. J Med Virol. 2005 Sep;77(1):47-52.
Abstract \| PubMed

48. Sendi H, Mehrab-Mohseni M, Zali MR, Norder H, Magnius LO. T1764G1766 core promoter double mutants are restricted to Hepatitis B virus strains with an A1757 and are common in genotype D. J Gen Virol. 2005 Sep;86(Pt 9):2451-8.
Abstract \| PubMed

47. Vincentelli R, Canaan S, Offant J, Cambillau C, Bignon C. Automated expression and solubility screening of His-tagged proteins in 96-well format. Anal Biochem. 2005 Nov 1;346(1):77-84. Epub 2005 Aug 15.
Abstract \| PubMed

46. Severson W, Xu X, Kuhn M, Senutovitch N, Thokala M, Ferron F, Longhi S, Canard B, Jonsson CB. Essential amino acids of the hantaan virus N protein in its interaction with RNA. J Virol. 2005 Aug;79(15):10032-9.
Abstract \| PubMed

45. Bourhis JM, Receveur-Brechot V, Oglesbee M, Zhang X, Buccellato M, Darbon H, Canard B, Finet S, Longhi S. The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predominantly unfolded. Protein Sci. 2005 Aug;14(8):1975-92.
Abstract \| PubMed

44. Cantaloube JF, Gallian P, Attoui H, Biagini P, De Micco P, de Lamballerie X. Genotype distribution and molecular epidemiology of hepatitis C virus in blood donors from southeast France. J Clin Microbiol. 2005 Aug;43(8):3624-9.
Abstract \| PubMed

43. Hass M, Hannoun C, Kalinina T, Sommer G, Manegold C, Gunther S. Functional analysis of hepatitis B virus reactivating in hepatitis B surface antigen-negative individuals. Hepatology. 2005 Jul;42(1):93-103.
Abstract \| PubMed

42. Charrel RN, Brouqui P, Foucault C, de Lamballerie X. Concurrent dengue and malaria. Emerg Infect Dis. 2005 Jul;11(7):1153-4.
Abstract \| PubMed

41. Al Faress S, Cartet G, Ferraris O, Norder H, Valette M, Lina B. Divergent genetic evolution of hemagglutinin in influenza A H1N1 and A H1N2 subtypes isolated in the south-France since the winter of 2001-2002. J Clin Virol. 2005 Jul;33(3):230-6.
Abstract \| PubMed

40. Chen L, Gui C, Luo X, Yang Q, Gunther S, Scandella E, Drosten C, Bai D, He X, Ludewig B, Chen J, Luo H, Yang Y, Yang Y, Zou J, Thiel V, Chen K, Shen J, Shen X, Jiang H. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun;79(11):7095-103.
Abstract \| PubMed

39. Higgs S, Schneider BS, Vanlandingham DL, Klingler KA, Gould EA. Nonviremic transmission of West Nile virus. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8871-4
Abstract \| PubMed

38. Laine D, Bourhis JM, Longhi S, Flacher M, Cassard L, Canard B, Sautes-Fridman C, Rabourdin-Combe C, Valentin H. Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively. J Gen Virol. 2005 Jun;86(Pt 6):1771-84.
Abstract \| PubMed

37. Klempa B, Stanko M, Labuda M, Ulrich R, Meisel H, Kruger DH. Central European Dobrava Hantavirus isolate from a striped field mouse (Apodemus agrarius). J Clin Microbiol. 2005 Jun;43(6):2756-63.
Abstract \| PubMed

36. Jeudy S, Coutard B, Lebrun R, Abergel C Acanthamoeba polyphaga mimivirus NDK: preliminary crystallographic analysis of the first viral nucleoside diphosphate kinase. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt 6):569-72
Abstract \| PubMed

35. Charrel RN, Zaki AM, Fakeeh M, Yousef AI, de Chesse R, Attoui H, de Lamballerie X. Low diversity of Alkhurma hemorrhagic fever virus, Saudi Arabia, 1994-1999. Emerg Infect Dis. 2005 May;11(5):683-8.
Abstract \| PubMed

34. Rodriguez-Roche R, Alvarez M, Holmes EC, Bernardo L, Kouri G, Gould EA, Halstead S, Guzman MG. Dengue virus type 3, Cuba, 2000-2002. Emerg Infect Dis. 2005 May;11(5):773-4.
Abstract \| PubMed

33. van den Born E, Posthuma CC, Gultyaev AP, Snijder EJ. Discontinuous subgenomic RNA synthesis in arteriviruses is guided by an RNA hairpin structure located in the genomic leader region. J Virol. 2005 May;79(10):6312-24.
Abstract \| PubMed

32. Mohd Jaafar F, Attoui H, Mertens PP, de Micco P, de Lamballerie X. Identification and functional analysis of VP3, the guanylyltransferase of Banna virus (genus Seadornavirus, family Reoviridae). J Gen Virol. 2005 Apr;86(Pt 4):1141-6.
Abstract \| PubMed

31. Mohd Jaafar F, Attoui H, Mertens PP, de Micco P, de Lamballerie X. Structural organization of an encephalitic human isolate of Banna virus (genus Seadornavirus, family Reoviridae). J Gen Virol. 2005 Apr;86(Pt 4):1147-57.
Abstract \| PubMed

30. Dussart P, Cartet G, Huguet P, Leveque N, Hajjar C, Morvan J, Vanderkerckhove J, Ferret K, Lina B, Chomel JJ, Norder H. Outbreak of acute hemorrhagic conjunctivitis in French Guiana and West Indies caused by coxsackievirus A24 variant: phylogenetic analysis reveals Asian import. J Med Virol. 2005 Apr;75(4):559-65.
Abstract \| PubMed

29. Rohayem J, Munch J, Rethwilm A. Evidence of recombination in the norovirus capsid gene. J Virol. 2005 Apr;79(8):4977-90.
Abstract \| PubMed

28. Rodriguez-Roche R, Alvarez M, Gritsun T, Halstead S, Kouri G, Gould EA, Guzman MG. Virus evolution during a severe dengue epidemic in Cuba, 1997. Virology. 2005 Apr 10;334(2):154-9.
Abstract \| PubMed

27. Keyaerts E, Vijgen L, Maes P, Neyts J, Van Ranst M. Growth kinetics of SARS-coronavirus in Vero E6 cells. Biochem Biophys Res Commun. 2005 Apr 15;329(3):1147-51.
Abstract \| PubMed

26. Ferron F, Rancurel C, Longhi S, Cambillau C, Henrissat B, Canard B. VaZyMolO: a tool to define and classify modularity in viral proteins. J Gen Virol. 2005 Mar;86(Pt 3):743-9.
Abstract \| PubMed

25. Vieth S, Drosten C, Charrel R, Feldmann H, Gunther S. Establishment of conventional and fluorescence resonance energy transfer-based real-time PCR assays for detection of pathogenic New World arenaviruses. J Clin Virol. 2005 Mar;32(3):229-35.
Abstract \| PubMed

24. Rodriguez-Roche R, Alvarez M, Gritsun T, Rosario D, Halstead S, Kouri G, Gould EA, Guzman MG. Dengue virus type 2 in Cuba, 1997: conservation of E gene sequence in isolates obtained at different times during the epidemic. Arch Virol. 2005 Mar;150(3):415-25.
Abstract \| PubMed

23. Ying C, Holy A, Hockova D, Havlas Z, De Clercq E, Neyts J. Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities. Antimicrob Agents Chemother. 2005 Mar;49(3):1177-80
Abstract \| PubMed

22. Dutartre H, Boretto J, Guillemot JC, Canard B. A relaxed discrimination of 2'-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B. J Biol Chem. 2005 Feb 25;280(8):6359-68.
Abstract \| PubMed

21. Priet S, Gros N, Navarro JM, Boretto J, Canard B, Querat G, Sire J. HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle. Mol Cell. 2005 Feb 18;17(4):479-90
Abstract \| PubMed

20. Leyssen P, Balzarini J, De Clercq E, Neyts J. The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. J Virol. 2005 Feb;79(3):1943-7.
Abstract \| PubMed

19. Deval J, Alvarez K, Selmi B, Bermond M, Boretto J, Guerreiro C, Mulard L, Canard B. Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using alpha-boranophosphate nucleoside analogs. J Biol Chem. 2005 Feb 4;280(5):3838-46.
Abstract \| PubMed

18. Mapelli M, Panjikar S, Tucker PA. The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding. J Biol Chem. 2005 Jan 28;280(4):2990-7.
Abstract \| PubMed

17. Groneberg DA, Hilgenfeld R, Zabel P. Molecular mechanisms of severe acute respiratory syndrome (SARS). Respir Res. 2005 Jan 20;6:8.
Abstract \| PubMed

16. Siddell, S. G., J. Ziebuhr and E. J. Snijder. Coronaviruses, toroviruses, and arteriviruses. Topley & Wilson's Microbiology (10th edition; volume 1), pp 823-856.
Abstract \| Link

15. Bessaud M, Grard G, Peyrefitte CN, Pastorino B, Rolland D, Charrel RN, de Lamballerie X, Tolou HJ. Identification and enzymatic characterization of NS2B-NS3 protease of Alkhurma virus, a class-4 flavivirus. Virus Res. 2005 Jan;107(1):57-62.
Abstract \| PubMed

14. Schmidt J, Jandrig B, Klempa B, Yoshimatsu K, Arikawa J, Meisel H, Niedrig M, Pitra C, Kruger DH, Ulrich R. Nucleocapsid protein of cell culture-adapted Seoul virus strain 80-39: analysis of its encoding sequence, expression in yeast and immuno-reactivity. Virus Genes. 2005 Jan;30(1):37-48.
Abstract \| PubMed

13. Liefeldt L, Plentz A, Klempa B, Kershaw O, Endres AS, Raab U, Neumayer HH, Meisel H, Modrow S. Recurrent high level parvovirus B19/genotype 2 viremia in a renal transplant recipient analyzed by real-time PCR for simultaneous detection of genotypes 1 to 3. J Med Virol. 2005 Jan;75(1):161-9.
Abstract \| PubMed

12. E. J. Snijder, S. G. Siddell, and A. E. Gorbalenya. The order Nidovirales. Topley & Wilson\'s Microbiology (10th edition; volume 1), pp 390-404.
Abstract \| Link

11. Seybert A, Posthuma CC, van Dinten LC, Snijder EJ, Gorbalenya AE, Ziebuhr J. A complex zinc finger controls the enzymatic activities of nidovirus helicases. J Virol. 2005 Jan;79(2):696-704.
Abstract \| PubMed

10. Barral K, Courcambeck J, Pepe G, Balzarini J, Neyts J, De Clercq E, Camplo M. Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides. J Med Chem. 2005 Jan 27;48(2):450-6
Abstract \| PubMed

9. Mohd Jaafar F, Attoui H, Bahar MW, Siebold C, Sutton G, Mertens PP, De Micco P, Stuart DI, Grimes JM, De Lamballerie X. The structure and function of the outer coat protein VP9 of Banna virus. Structure. 2005 Jan;13(1):17-28.
Abstract \| PubMed \| PDB

8. Hass M, Golnitz U, Muller S, Becker-Ziaja B, Gunther S. Replicon system for Lassa virus. J Virol. 2004 Dec;78(24):13793-803.
Abstract \| PubMed

7. Charrel RN, Attoui H, Butenko AM, Clegg JC, Deubel V, Frolova TV, Gould EA, Gritsun TS, Heinz FX, Labuda M, Lashkevich VA, Loktev V, Lundkvist A, Lvov DV, Mandl CW, Niedrig M, Papa A, Petrov VS, Plyusnin A, Randolph S, Suss J, Zlobin VI, de Lamballerie X. Tick-borne virus diseases of human interest in Europe. Clin Microbiol Infect. 2004 Dec;10(12):1040-55.
Abstract \| PubMed

6. Norder H, Courouce AM, Coursaget P, Echevarria JM, Lee SD, Mushahwar IK, Robertson BH, Locarnini S, Magnius LO. Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes. Intervirology. 2004 Nov-Dec;47(6):289-309.
Abstract \| PubMed

5. Gunther S, Lenz O. Lassa virus. Crit Rev Clin Lab Sci. 2004;41(4):339-90.
Abstract \| PubMed

4. Oberste MS, Michele SM, Maher K, Schnurr D, Cisterna D, Junttila N, Uddin M, Chomel JJ, Lau CS, Ridha W, al-Busaidy S, Norder H, Magnius LO, Pallansch MA. Molecular identification and characterization of two proposed new enterovirus serotypes, EV74 and EV75. J Gen Virol. 2004 Nov;85(Pt 11):3205-12.
Abstract \| PubMed

3. Benarroch D, Selisko B, Locatelli GA, Maga G, Romette JL, Canard B. The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core. Virology. 2004 Oct 25;328(2):208-18.
Abstract \| PubMed

2. Gunther S, Asper M, Roser C, Luna LK, Drosten C, Becker-Ziaja B, Borowski P, Chen HM, Hosmane RS. Application of real-time PCR for testing antiviral compounds against Lassa virus, SARS coronavirus and Ebola virus in vitro. Antiviral Res. 2004 Sep;63(3):209-15.
Abstract \| PubMed

1. Butan C, Van Der Zandt H, Tucker PA. Structure and assembly of the RNA binding domain of bluetongue virus non-structural protein 2. J Biol Chem. 2004 Sep 3;279(36):37613-21.
Abstract \| PubMed

Publications des partenaires du projet VIZIER, dans le domaine de la virologie et de la génomique structurale

(mercredi 22 novembre 2006)

Post-Scriptum