VIZIER:Publications des partenaires du projet VIZIER, dans le domaine de la virologie et de la génomique structurale

178. De Palma AM, Heggermont W, Lanke K, Coutard B, Bergmann M, Monforte AM, Canard B, De Clercq E, Chimirri A, Pürstinger G, Rohayem J, van Kuppeveld F, Neyts J. The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C. J Virol
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177. Forrester NL, Moss SR, Turner SL, Schirrmeier H, Gould EA. Recombination in rabbit haemorrhagic disease virus: Possible impact on evolution and epidemiology. Virology. 2008 May 1.
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176. Decroly E, Imbert I, Coutard B, Bouvet M, Selisko B, Alvarez K, Gorbalenya AE, Snijder EJ, Canard B. Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity. J. Virol
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175. elmas O, Holmes EC, Talbi C, Larrous F, Dacheux L, Bouchier C, Bourhy H. Genomic diversity and evolution of the Lyssaviruses. PLoS ONE. 2008 Apr 30;3(4):e2057.
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174. Assenberg R, Delmas O, Graham SC, Verma A, Berrow N, Stuart DI, Owens RJ, Bourhy H, Grimes JM. Expression, purification and crystallization of a lyssavirus matrix (M) protein. Acta F
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173. de Lamballerie X, Leroy E, Charrel RN, Ttsetsarkin K, Higgs S, Gould EA. Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come? Virol J. 2008 Feb 27;5:33.
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172. Speroni S, De Colibus L, Mastrangelo E, Gould E, Coutard B, Forrester NL, Blanc S, Canard B, Mattevi A. Structure and biochemical analysis of Kokobera virus helicase. Proteins. 2008 Feb 15;70(3):1120-3.
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171. Leontovich AM, Tokmachev KY, van Houwelingen HC. The comparative analysis of statistics, based on the likelihood ratio criterion, in the automated annotation problem. BMC Bioinformatics. 2008 Jan 22;9:31.
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170. Mumtsidu E, Makhov AM, Roessle M, Bathke A, Tucker PA. Structural features of the Bluetongue virus NS2 protein. J Struct Biol. 2007 Nov;160(2):157-67.
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169. Mancini EJ, Assenberg R, Verma A, Walter TS, Tuma R, Grimes JM, Owens RJ, Stuart DI. Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution. Protein Sci. 2007 Oct;16(10):2294-300.
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168. Jiang P, Faase JA, Toyoda H, Paul A, Wimmer E, Gorbalenya AE. Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication. PNAS U S A. 2007 May 29;104(22):9457-62.
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167. Assenberg R, Ren J, Verma A, Walter TS, Alderton D, Hurrelbrink RJ, Fuller SD, Bressanelli S, Owens RJ, Stuart DI, Grimes JM. Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. J Gen Virol. 2007 Aug;88(Pt 8):2228-36.
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166. Grard G, Moureau G, Charrel RN, Lemasson JJ, Gonzalez JP, Gallian P, Gritsun TS, Holmes EC, Gould EA, de Lamballerie X. Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy. Virology. 2007 Apr 25;361(1):80-92.
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165. Fullerton SW, Blaschke M, Coutard B, Gebhardt J, Gorbalenya A, Canard B, Tucker PA, Rohayem J. Structural and functional characterization of sapovirus RNA-dependent RNA polymerase. J Virol. 2007 Feb;81(4):1858-71.
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164.

Coutard B, Gorbalenya AE, Snijder EJ, Leontovich AM, Poupon A, De Lamballerie X, Charrel R, Gould EA, Gunther S, Norder H, Klempa B, Bourhy H, Rohayem J, L'hermite E, Nordlund P, Stuart DI, Owens RJ, Grimes JM, Tucker PA, Bolognesi M, Mattevi A, Coll M, Jones TA, Aqvist J, Unge T, Hilgenfeld R, Bricogne G, Neyts J, La Colla P, Puerstinger G, Gonzalez JP, Leroy E, Cambillau C, Romette JL, Canard B.

The VIZIER project: Preparedness against pathogenic RNA viruses.

Antiviral Res.

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163. Care S, Bignon C, Pelissier MC, Blanc E, Canard B, Coutard B. The translation of recombinant proteins in E. coli can be improved by in silico generating and screening random libraries of a 70/+96 mRNA region with respect to the translation initiation codon. Nucleic Acids Res.
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162.

Paeshuyse J, Chezal JM, Froeyen M, Leyssen P, Dutartre H, Vrancken R, Canard B, Letellier C, Li T, Mittendorfer H, Koenen F, Kerkhofs P, De Clercq E, Herdewijn P, Puerstinger G, Gueiffier A, Chavignon O, Teulade JC, Neyts J.

The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.

Journal of Virology, Oct. 2007, p. 11046-11053

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161. Egloff MP, Decroly E, Malet H, Selisko B, Benarroch D, Ferron F, Canard B. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. J Mol Biol. 2007 Sep 21;372(3):723-36. Epub 2007 Jul 12.
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160. Mastrangelo E, Milani M, Bollati M, Selisko B, Peyrane F, Pandini V, Sorrentino G, Canard B, Konarev PV, Svergun DI, de Lamballerie X, Coutard B, Khromykh AA, Bolognesi M. Crystal structure and activity of kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein. J Mol Biol. 2007 Sep 14;372(2):444-55. Epub 2007 Jun 27.
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159. Beerens N, Selisko B, Ricagno S, Imbert I, van der Zanden L, Snijder EJ, Canard B. De novo initiation of RNA synthesis by the arterivirus RNA-dependent RNA polymerase J Virol. 2007 Aug;81(16):8384-95. Epub 2007 May 30.
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158. Assenberg R, Ren J, Verma A, Walter TS, Alderton D, Hurrelbrink RJ, Fuller SD, Bressanelli S, Owens RJ, Stuart DI, Grimes JM. Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase J Gen Virol. 2007 Aug;88(Pt 8):2228-36.
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157. Mastrangelo E, Bollati M, Milani M, Selisko B, Peyrane F, Canard B, Grard G, de Lamballerie X, Bolognesi M. Structural bases for substrate recognition and activity in Meaban virus nucleoside-2'-O-methyltransferase. Protein Sci. 2007 Jun;16(6):1133-45. Epub 2007 May 1.Click here to read
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156. Malet H, Egloff MP, Selisko B, Butcher RE, Wright PJ, Roberts M, Gruez A, Sulzenbacher G, Vonrhein C, Bricogne G, Mackenzie JM, Khromykh AA, Davidson AD, Canard B. Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5. J Biol Chem. 2007 Apr;282(14):10678-89. Epub 2007 Feb 7.
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155. De Colibus L, Speroni S, Coutard B, Forrester NL, Gould E, Canard B, Mattevi A Purification and crystallization of Kokobera virus helicase Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):193-5.
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154. Sutton G, Grimes JM, Stuart DI, Roy P. Bluetongue virus VP4 is an RNA-capping assembly line. Nat Struct Mol Biol. 2007 May;14(5):449-51.
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153. Nick S. Berrow, David Alderton, Sarah Sainsbury, Joanne Nettleship, Rene Assenberg, Nahid Rahman, David I. Stuart, and Raymond J. Owens A versatile ligation-independent cloning method suitable for high-throughput expression screening applications Nucleic Acids Res. 2007 Mar 12; [Epub ahead of print]
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152. Yap TL, Xu T, Chen YL, Malet H, Egloff MP, Canard B, Vasudevan SG, Lescar J. Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. J Virol. 2007 May;81(9):4753-65. Epub 2007 Feb 14.
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151. Peyrane F, Selisko B, Decroly E, Vasseur JJ, Benarroch D, Canard B, Alvarez K High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions Nucleic Acids Res. 2007 Jan 26; [Epub ahead of print]
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150. Biagini P, de Lamballerie X, de Micco P. Effective detection of highly divergent viral genomes in infected cell lines using a new subtraction strategy (primer extension enrichment reaction-PEER). J Virol Methods. 2007 Jan;139(1):106-10. Epub 2006 Oct 25
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149. Barral K, Priet S, Sire J, Neyts J, Balzarini J, Canard B, Alvarez K. Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine. J Med Chem. 2006 Dec 28;49(26):7799-7806.
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148. Palma AM, Heggermont W, Leyssen P, Purstinger G, Wimmer E, Clercq ED, Rao A, Monforte AM, Chimirri A, Neyts J. Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles. Biochem Biophys Res Commun. 2006 Dec 19
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147. Dutartre H, Bussetta C, Boretto J, Canard B. General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2'-modified nucleotide analogues. Antimicrob Agents Chemother. 2006 Dec;50(12):4161-9.
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146. Emmerich P, Thome-Bolduan C, Drosten C, Gunther S, Ban E, Sawinsky I, Schmitz H. Reverse ELISA for IgG and IgM antibodies to detect Lassa virus infections in Africa. J Clin Virol. 2006 Dec;37(4):277-81.
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145. Hass M, Westerkofsky M, Muller S, Becker-Ziaja B, Busch C, Gunther S. Mutational analysis of the lassa virus promoter. J Virol. 2006 Dec;80(24):12414-9.
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144. Mesters JR, Tan J, Hilgenfeld R. Viral enzymes. Curr Opin Struct Biol. 2006 Dec;16(6):776-86.
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143. Stikleryte A, Griskeviciene J, Magnius LO, Zagminas K, Norder H, Ambrozaitis A. Characterization of HCV strains in an oncohematological pediatric department reveals little horizontal transmission but multiple introductions by un-screened blood products in the past. J Med Virol. 2006 Nov;78(11):1411-22.
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142. Sassenscheidt J, Rohayem J, Illmer T, Bandt D. Detection of beta-herpesviruses in allogenic stem cell recipients by quantitative real-time PCR. J Virol Methods. 2006 Dec;138(1-2):40-8.
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141. van Aken D, Zevenhoven-Dobbe J, Gorbalenya AE, Snijder EJ. Proteolytic maturation of replicase polyprotein pp1a by the nsp4 main proteinase is essential for equine arteritis virus replication and includes internal cleavage of nsp7. J Gen Virol. 2006 Dec;87(Pt 12):3473-82.
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140. Mesters JR, Tan J, Hilgenfeld R. Viral enzymes. Curr Opin Struct Biol. 2006 Dec;16(6):776-86. Epub 2006 Nov 7
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139. Fullerton SW, Blaschke M, Coutard B, Gebhardt J, Gorbalenya A, Canard B, Tucker PA, Rohayem J. STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF SAPOVIRUS RNA-DEPENDENT RNA POLYMERASE. J Virol. 2006 Nov 22
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138. Grard G, Lemasson JJ, Sylla M, Dubot A, Cook S, Molez JF, Pourrut X, Charrel R, Gonzalez JP, Munderloh U, Holmes EC, de Lamballerie X. Ngoye virus: a novel evolutionary lineage within the genus Flavivirus. J Gen Virol. 2006 Nov;87(Pt 11):3273-7.
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137. Gritsun TS, Gould EA. Direct repeats in the 3' untranslated regions of mosquito-borne flaviviruses: possible implications for virus transmission. J Gen Virol. 2006 Nov;87(Pt 11):3297-305.
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136. Pattamadilok S, Lee BH, Kumperasart S, Yoshimatsu K, Okumura M, Nakamura I, Araki K, Khoprasert Y, Dangsupa P, Panlar P, Jandrig B, Kruger DH, Klempa B, Jakel T, Schmidt J, Ulrich R, Kariwa H, Arikawa J. Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus. Am J Trop Med Hyg. 2006 Nov;75(5):994-1002.
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135. Tataridis D, Fytas G, Kolocouris A, Fytas C, Kolocouris N, Foscolos GB, Padalko E, Neyts J, De Clercq E. Influence of an additional 2-amino substituent of the 1-aminoethyl pharmacophore group on the potency of rimantadine against influenza virus A. Bioorg Med Chem Lett. 2006 Nov 2
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134. Ying C, Colonno R, De Clercq E, Neyts J. Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir. Antiviral Res. 2006 Oct 30
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133. Puerstinger G, Paeshuyse J, De Clercq E, Neyts J. Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: From anti-pestivirus to anti-hepatitis C virus activity. Bioorg Med Chem Lett. 2006 Oct 19
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132. Puerstinger G, Paeshuyse J, Herdewijn P, Rozenski J, De Clercq E, Neyts J. Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5345-9
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131. Geerlof A, Brown J, Coutard B, Egloff MP, Enguita FJ, Fogg MJ, Gilbert RJ, Groves MR, Haouz A, Nettleship JE, Nordlund P, Owens RJ, Ruff M, Sainsbury S, Svergun DI, Wilmanns M. The impact of protein characterization in structural proteomics. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1125-36
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130. Berrow NS, Bussow K, Coutard B, Diprose J, Ekberg M, Folkers GE, Levy N, Lieu V, Owens RJ, Peleg Y, Pinaglia C, Quevillon-Cheruel S, Salim L, Scheich C, Vincentelli R, Busso D. Recombinant protein expression and solubility screening in Escherichia coli: a comparative study. Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1218-26
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129. Ferron F, Longhi S, Canard B, Karlin D. A practical overview of protein disorder prediction methods. Proteins. 2006 Oct 1;65(1):1-14.
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128.

Fogg MJ, Alzari P, Bahar M, Bertini I, Betton JM, Burmeister WP, Cambillau C, Canard B, Carrondo M, Coll M, Daenke S, Dym O, Egloff MP, Enguita FJ, Geerlof A, Haouz A, Jones TA, Ma Q, Manicka SN, Migliardi M, Nordlund P, Owens RJ, Peleg Y, Schneider G, Schnell R, Stuart DI, Tarbouriech N, Unge T, Wilkinson AJ, Wilmanns M, Wilson KS, Zimhony O, Grimes JM.

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1196-207

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127. Imbert I, Guillemot JC, Bourhis JM, Bussetta C, Coutard B, Egloff MP, Ferron F, Gorbalenya AE, Canard B. A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus. EMBO J. 2006 Oct 18;25(20):4933-42
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126. Scandella E, Eriksson KK, Hertzig T, Drosten C, Chen L, Gui C, Luo X, Shen J, Shen X, Siddell SG, Ludewig B, Jiang H, Gunther S, Thiel V. Identification and evaluation of coronavirus replicase inhibitors using a replicon cell line. Adv Exp Med Biol. 2006;581:609-13.
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125. Ponnusamy R, Mesters JR, Ziebuhr J, Moll R, Hilgenfeld R. Non structural proteins 8 and 9 of human coronavirus 229E. Adv Exp Med Biol. 2006;581:49-54.
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124. Piotrowski Y, van der Hoek L, Pyrc K, Berkhout B, Moll R, Hilgenfeld R. Nonstructural proteins of human coronavirus NL63. Adv Exp Med Biol. 2006;581:97-100.
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123. Hilgenfeld R, Anand K, Mesters JR, Rao Z, Shen X, Jiang H, Tan J, Verschueren KH. Structure and dynamics of SARS coronavirus main proteinase (Mpro). Adv Exp Med Biol. 2006;581:585-91
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122. Morice Y, Cantaloube JF, Beaucourt S, Barbotte L, De Gendt S, Goncales FL, Butterworth L, Cooksley G, Gish RG, Beaugrand M, Fay F, Fay O, Gonzalez JE, Martins RM, Dhumeaux D, Vanderborght B, Stuyver L, Sablon E, de Lamballerie X, Pawlotsky JM. Molecular epidemiology of hepatitis C virus subtype 3a in injecting drug users. J Med Virol. 2006 Oct;78(10):1296-303.
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121. Marriott L, Willoughby K, Chianini F, Dagleish MP, Scholes S, Robinson AC, Gould EA, Nettleton PF. Detection of Louping ill virus in clinical specimens from mammals and birds using TaqMan RT-PCR. J Virol Methods. 2006 Oct;137(1):21-8.
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120. Forrester NL, Trout RC, Gould EA. Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire. Virology. 2006 Oct 12
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119. Gritsun TS, Gould EA. The 3' untranslated region of tick-borne flaviviruses originated by the duplication of long repeat sequences within the open reading frame. Virology. 2006 Oct 10;354(1):217-23.
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118. Goris N, De Palma A, Toussaint JF, Musch I, Neyts J, De Clercq K. 2'-C-Methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus. Antiviral Res. 2006 Oct 10
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117. Charrel RN, Retornaz K, Emonet S, Noel G, Chaumoitre K, Minodier P, Girard N, Garnier JM, de Lamballerie X. Acquired hydrocephalus caused by a variant lymphocytic choriomeningitis virus. Arch Intern Med. 2006 Oct 9;166(18):2044-6.
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116. Setaki D, Tataridis D, Stamatiou G, Kolocouris A, Foscolos GB, Fytas G, Kolocouris N, Padalko E, Neyts J, De Clercq E. Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles. Bioorg Chem. 2006 Oct;34(5):248-73
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115. Coelmont L, Paeshuyse J, Windisch MP, De Clercq E, Bartenschlager R, Neyts J. Ribavirin antagonizes the in vitro anti-hepatitis C virus activity of 2'-C-methylcytidine, the active component of valopicitabine. Antimicrob Agents Chemother. 2006 Oct;50(10):3444-6
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114. Paeshuyse J, Coelmont L, Vliegen I, Van hemel J, Vandenkerckhove J, Peys E, Sas B, De Clercq E, Neyts J. Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin. Biochem Biophys Res Commun. 2006 Sep 15;348(1):139-44
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113. Egloff MP, Malet H, Putics A, Heinonen M, Dutartre H, Frangeul A, Gruez A, Campanacci V, Cambillau C, Ziebuhr J, Ahola T, Canard B. Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains. J Virol. 2006 Sep;80(17):8493-502.
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112. Marschenz S, Endres AS, Brinckmann A, Heise T, Kristiansen G, Nurnberg P, Kruger DH, Gunther S, Meisel H. Functional analysis of complex hepatitis B virus variants associated with development of liver cirrhosis. Gastroenterology. 2006 Sep;131(3):765-80.
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111. Gritsun TS, Gould EA. The 3' untranslated regions of Kamiti River virus and Cell fusing agent virus originated by self-duplication. J Gen Virol. 2006 Sep;87(Pt 9):2615-9.
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110. Buckley A, Dawson A, Gould EA. Detection of seroconversion to West Nile virus, Usutu virus and Sindbis virus in UK sentinel chickens. Virol J. 2006 Sep 4;3:71.
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109. Rohayem J, Jager K, Robel I, Scheffler U, Temme A, Rudolph W. Characterization of norovirus 3Dpol RNA-dependent RNA polymerase activity and initiation of RNA synthesis. J Gen Virol. 2006 Sep;87(Pt 9):2621-30.
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108. van Aken D, Benckhuijsen WE, Drijfhout JW, Wassenaar AL, Gorbalenya AE, Snijder EJ. Expression, purification, and in vitro activity of an arterivirus main proteinase. Virus Res. 2006 Sep;120(1-2):97-106. Epub 2006 Mar 9.
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107. Neyts J. Selective inhibitors of hepatitis C virus replication. Antiviral Res. 2006 Sep;71(2-3):363-71
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106. Mastrangelo E, Bollati M, Milani M, Brisbarre N, de Lamballerie X, Coutard B, Canard B, Khromykh A, Bolognesi M. Preliminary crystallographic characterization of an RNA helicase from Kunjin virus. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):876-9.
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105. Ricagno S, Egloff MP, Ulferts R, Coutard B, Nurizzo D, Campanacci V, Cambillau C, Ziebuhr J, Canard B. Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11892-7
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104. Charrel RN, Izri A, Temmam S, de Lamballerie X, Parola P. Toscana virus RNA in Sergentomyia minuta files. Emerg Infect Dis. 2006 Aug;12(8):1299-300.
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103. Ottoson J, Hansen A, Westrell T, Johansen K, Norder H, Stenstrom TA. Removal of noro- and enteroviruses, Giardia cysts, Cryptosporidium oocysts, and fecal indicators at four secondary wastewater treatment plants in Sweden. Water Environ Res. 2006 Aug;78(8):828-34.
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102. Rohayem J, Dumke R, Jaeger K, Schroter-Bobsin U, Mogel M, Kruse A, Jacobs E, Rethwilm A. Assessing the risk of transmission of viral diseases in flooded areas: viral load of the River Elbe in Dresden during the flood of August 2002. Intervirology. 2006;49(6):370-6.
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101. Mastrangelo E, Bollati M, Milani M, de Lamballeire X, Brisbare N, Dalle K, Lantez V, Egloff MP, Coutard B, Canard B, Gould E, Forrester N, Bolognesi M. Preliminary characterization of (nucleoside-2-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):768-70
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100. Selisko B, Dutartre H, Guillemot JC, Debarnot C, Benarroch D, Khromykh A, Despres P, Egloff MP, Canard B. Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases. Virology. 2006 Jul 20;351(1):145-58
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99. Meier C, Aricescu AR, Assenberg R, Aplin RT, Gilbert RJ, Grimes JM, Stuart DI The Crystal Structure of ORF-9b, a Lipid Binding Protein from the SARS Coronavirus. Structure. 2006 Jul;14(7):1157-1165.
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98. Al-Gharabli SI, Shah ST, Weik S, Schmidt MF, Mesters JR, Kuhn D, Klebe G, Hilgenfeld R, Rademann J. An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors. Chembiochem. 2006 Jul;7(7):1048-55.
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97. de Lamballerie X, Colson P. The battle against infectious diseases in developing countries: the inseparable twins of diagnosis and therapy.de Lamballerie X, Colson P. Clin Chem. 2006 Jul;52(7):1217.
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96. Beerens N, Snijder EJ. RNA signals in the 3' terminus of the genome of Equine arteritis virus are required for viral RNA synthesis. J Gen Virol. 2006 Jul;87(Pt 7):1977-83.
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95. Rohayem J, Robel I, Jager K, Scheffler U, Rudolph W. Protein-primed and de novo initiation of RNA synthesis by norovirus 3Dpol. J Virol. 2006 Jul;80(14):7060-9.
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94. Matthes N, Mesters JR, Coutard B, Canard B, Snijder EJ, Moll R, Hilgenfeld R. The non-structural protein Nsp10 of mouse hepatitis virus binds zinc ions and nucleic acids. FEBS Lett. 2006 Jul 24;580(17):4143-9. Epub 2006 Jun 30.
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93. Charrel RN, Zaki AM, Fagbo S, de Lamballerie X. Alkhurma hemorrhagic fever virus is an emerging tick-borne flavivirus. J Infect. 2006 Jun;52(6):463-4.
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92. Cantaloube JF, Laperche S, Gallian P, Bouchardeau F, de Lamballerie X, de Micco P. Analysis of the 5' noncoding region versus the NS5b region in genotyping hepatitis C virus isolates from blood donors in France. J Clin Microbiol. 2006 Jun;44(6):2051-6.
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91. Snijder EJ, van der Meer Y, Zevenhoven-Dobbe J, Onderwater JJ, van der Meulen J, Koerten HK, Mommaas AM. Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. J Virol. 2006 Jun;80(12):5927-40.
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90. Pasternak AO, Spaan WJ, Snijder EJ. Nidovirus transcription: how to make sense...? J Gen Virol. 2006 Jun;87(Pt 6):1403-21.
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89. Zoidis G, Fytas C, Papanastasiou I, Foscolos GB, Fytas G, Padalko E, De Clercq E, Naesens L, Neyts J, Kolocouris N. Heterocyclic rimantadine analogues with antiviral activity. Bioorg Med Chem. 2006 May 15;14(10):3341-8
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88. Attoui H, Jaafar FM, Belhouchet M, de Micco P, de Lamballerie X, Brussaard CP. Micromonas pusilla reovirus: a new member of the family Reoviridae assigned to a novel proposed genus (Mimoreovirus). J Gen Virol. 2006 May;87(Pt 5):1375-83.
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87. Klempa B, Fichet-Calvet E, Lecompte E, Auste B, Aniskin V, Meisel H, Denys C, Koivogui L, ter Meulen J, Kruger DH. Hantavirus in African wood mouse, Guinea. Emerg Infect Dis. 2006 May;12(5):838-40.
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86. Tabarrini O, Manfroni G, Fravolini A, Cecchetti V, Sabatini S, De Clercq E, Rozenski J, Canard B, Dutartre H, Paeshuyse J, Neyts J. Synthesis and anti-BVDV activity of acridones as new potential antiviral agents. J Med Chem. 2006 Apr 20;49(8):2621-7.
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85. Emonet S, Grard G, Brisbarre N, Moureau G, Temmam S, Charrel R, de Lamballerie X. LoPPS: a long PCR product sequencing method for rapid characterisation of long amplicons. Biochem Biophys Res Commun. 2006 Jun 16;344(4):1080-5. Epub 2006 Apr 19.
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84. Cook S, Bennett SN, Holmes EC, De Chesse R, Moureau G, de Lamballerie X. Isolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto Rico. J Gen Virol. 2006 Apr;87(Pt 4):735-48.
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83. Gould EA, Higgs S, Buckley A, Gritsun TS. Potential arbovirus emergence and implications for the United Kingdom. Emerg Infect Dis. 2006 Apr;12(4):549-55.
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82. Ottoson J, Hansen A, Bjorlenius B, Norder H, Stenstrom TA. Removal of viruses, parasitic protozoa and microbial indicators in conventional and membrane processes in a wastewater pilot plant. Water Res. 2006 Apr;40(7):1449-57.
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81. Smits SL, Snijder EJ, de Groot RJ. Characterization of a torovirus main proteinase. J Virol. 2006 Apr;80(8):4157-67.
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80. Leyssen P, De Clercq E, Neyts J. The anti-yellow fever virus activity of ribavirin is independent of error-prone replication. Mol Pharmacol. 2006 Apr;69(4):1461-7
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79. Paeshuyse J, Kaul A, De Clercq E, Rosenwirth B, Dumont JM, Scalfaro P, Bartenschlager R, Neyts J. The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology. 2006 Apr;43(4):761-70
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78. Ricagno S, Coutard B, Grisel S, Bremond N, Dalle K, Tocque F, Campanacci V, Lichiere J, Lantez V, Debarnot C, Cambillau C, Canard B, Egloff MP. Crystallization and preliminary X-ray diffraction analysis of Nsp15 from SARS coronavirus. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt 4):409-11
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77. Malet H, Dalle K, Bremond N, Tocque F, Blangy S, Campanacci V, Coutard B, Grisel S, Lichiere J, Lantez V, Cambillau C, Canard B, Egloff MP. Expression, purification and crystallization of the SARS-CoV macro domain. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt 4):405-8
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76. Minskaia E, Hertzig T, Gorbalenya AE, Campanacci V, Cambillau C, Canard B, Ziebuhr J. Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5108-13
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75. Carta A, Loriga M, Piras S, Paglietti G, La Colla P, Busonera B, Collu G, Loddo R. Synthesis of variously substituted 3-phenoxymethyl quinoxalin-2-ones and quinoxalines capable to potentiate in vitro the antiproliferative activity of anticancer drugs in multi-drug resistant cell lines. Med Chem. 2006 Mar;2(2):113-22.
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74. Schmitz T, Kleinkauf N, Klempa B, Ringe H, Varnholt V, Grosch-Worner I. Transmission of human immunodeficiency virus type 1 nevirapine resistance mutation K103N from a treatment-naive mother to her child. Pediatr Infect Dis J. 2006 Mar;25(3):275-6.
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73. Gorbalenya AE, Enjuanes L, Ziebuhr J, Snijder EJ. Nidovirales: evolving the largest RNA virus genome. Virus Res. 2006 Apr;117(1):17-37. Epub 2006 Feb 28.
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72. Emonet S, Lemasson JJ, Gonzalez JP, de Lamballerie X, Charrel RN. Phylogeny and evolution of old world arenaviruses. Virology. 2006 Jul 5;350(2):251-7. Epub 2006 Feb 21.
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71. Feng JY, Myrick FT, Margot NA, Mulamba GB, Rimsky L, Borroto-Esoda K, Selmi B, Canard B. Virologic and enzymatic studies revealing the mechanism of K65R- and Q151M-associated HIV-1 drug resistance towards emtricitabine and lamivudine. Nucleosides Nucleotides Nucleic Acids. 2006;25(1):89-107.
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70. Biagini P, de Micco P, de Lamballerie X. Identification of a third member of the Anellovirus genus ("small anellovirus") in French blood donors. Arch Virol. 2006 Feb;151(2):405-8.
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Publications des partenaires du projet VIZIER, dans le domaine de la virologie et de la génomique structurale

(mercredi 22 novembre 2006)